Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a desensitizing therapy for IgE-mediated allergic diseases and represents a potentially curative way of treatment. The mechanisms of action of AIT include the induction of very early desensitization of mast cells and baso...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 133; no. 3; pp. 621 - 631
Main Authors:	Akdis, Mübeccel, Akdis, Cezmi A.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01.03.2014 Elsevier Elsevier Limited
Subjects:	allergen immunotherapy Allergens - immunology Allergies Allergy and Immunology Animals Asthma B cells B-Lymphocytes, Regulatory - immunology basophils Basophils - physiology Biological and medical sciences Biopsy Cytokines Desensitization, Immunologic Disease eosinophils Food allergies Forkhead Transcription Factors - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IgE IgG IL-10 Immune system Immune Tolerance Immunopathology Immunotherapy Interleukin-10 - physiology Ligands Lymphocytes mast cells Mast Cells - physiology Medical sciences Psoriasis Receptors, Histamine H2 - physiology Regulatory T cells Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis T cells T helper cells T-Lymphocytes, Regulatory - immunology TGF-β Transcription factors Transforming Growth Factor beta - physiology VIT PLA IgE IgG eosinophils HR basophils Regulatory T cells T cells mast cells SHP-1 Breg LPR immune tolerance immunotherapy TGF-β CTLA-4 TLR ICOS BR1 SLIT allergen immunotherapy Treg B cells AIT FOXP3 IL-10 pDC TR1 T helper cells PD-1 DC Src homology domain 2–containing protein tyrosine phosphatase 1 Programmed death 1 Forkhead box protein 3 Regulatory T IL-10–secreting regulatory B Histamine receptor Toll-like receptor Dendritic cell B R1 Inducible costimulator IL-10–secreting regulatory T Regulatory B Phospholipase A 2 T R1 Plasmacytoid dendritic cell Cytotoxic T lymphocyte antigen 4 Late-phase response Venom immunotherapy Sublingual immunotherapy Allergen-specific immunotherapy Allergy Transforming growth factor β Granulocyte Helper cell Basophil Mechanism Immunology Immunotherapy T-Lymphocyte Suppressor Regulatory cell Immunopathology Immunoglobulins Desensitization Multiple Cytokine B-Lymphocyte Eosinophil Treatment Immune tolerance Interleukin 10 Mast cell Allergen
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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