Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

Cryo-electron microscopy analysis of yeast Rad26 bound to RNA polymerase II provides insight into the initiation of the transcription-coupled DNA repair mechanism in eukaryotes. Transcription-coupled repair complex Transcription-coupled DNA repair removes DNA lesions from the template strand that pr...

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Bibliographic Details
Published in:	Nature (London) Vol. 551; no. 7682; pp. 653 - 657
Main Authors:	Xu, Jun, Lahiri, Indrajit, Wang, Wei, Wier, Adam, Cianfrocco, Michael A., Chong, Jenny, Hare, Alissa A., Dervan, Peter B., DiMaio, Frank, Leschziner, Andres E., Wang, Dong
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.11.2017 Nature Publishing Group
Subjects:	101/28 631/337/1427/1430 631/337/572 631/535/1258/1259 82/29 82/80 82/83 Adenosine triphosphatase Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism Adenosine Triphosphatases - ultrastructure Baking yeast Cockayne syndrome Cryoelectron Microscopy Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism DNA - ultrastructure DNA Repair DNA-directed RNA polymerase Electron microscopy Elongation Eukaryotes Genetic research Hereditary diseases Humanities and Social Sciences Lesions letter Microscopy multidisciplinary Mutation Nucleotide excision repair Photosensitivity Protein Domains Proteins Ribonucleic acid RNA RNA polymerase RNA polymerase II RNA Polymerase II - chemistry RNA Polymerase II - metabolism RNA Polymerase II - ultrastructure Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - ultrastructure Science Structure-function relationships Transcription (Genetics) Transcription elongation Transcription Elongation, Genetic Transcription Factors - chemistry Transcription Factors - metabolism Transcription initiation Transcription, Genetic Transcription-coupled repair Translocation Yeast
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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