Prevalence and Clinical Significance of HIV Drug Resistance Mutations by Ultra-Deep Sequencing in Antiretroviral-Naïve Subjects in the CASTLE Study

CASTLE compared the efficacy of atazanavir/ritonavir with lopinavir/ritonavir, each in combination with tenofovir-emtricitabine in ARV-naïve subjects from 5 continents. Determine the baseline rate and clinical significance of TDR mutations using ultra-deep sequencing (UDS) in ARV-naïve subjects in C...

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Bibliographic Details
Published in:	PloS one Vol. 5; no. 6; p. e10952
Main Authors:	Lataillade, Max, Chiarella, Jennifer, Yang, Rong, Schnittman, Steven, Wirtz, Victoria, Uy, Jonathan, Seekins, Daniel, Krystal, Mark, Mancini, Marco, McGrath, Donnie, Simen, Birgitte, Egholm, Michael, Kozal, Michael
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 03.06.2010 Public Library of Science (PLoS)
Subjects:	Antiretroviral agents Antiretroviral drugs Case depth Case-Control Studies CD4 antigen Clinical significance Continents Control methods Drug resistance Drug Resistance, Viral - genetics Emtricitabine HIV HIV - genetics HIV Infections - virology Human immunodeficiency virus Humans Infectious Diseases Infectious Diseases/Antimicrobials and Drug Resistance Infectious Diseases/HIV Infection and AIDS Lopinavir Low resistance Mutation Protease inhibitors Ritonavir Tenofovir Viral Load United States > US Connecticut
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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