Foveal avascular zone and vessel density in healthy subjects: An optical coherence tomography angiography study

Purpose: To report the normal characteristics and correlations of the foveal microvascular networks using optical coherence tomography angiography (OCTA) in a healthy Iranian population. Methods: Enface 3x3 OCTA images were obtained using the RTVue Avanti spectral-domain optical coherence tomography...

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Veröffentlicht in:Journal of ophthalmic & vision research Jg. 13; H. 3; S. 260 - 265
Hauptverfasser: Falavarjani, Khalil, Shenazandi, Hamideh, Naseri, Dariush, Anvari, Pasha, Kazemi, Pegah, Aghamohammadi, Farzaneh, Alissmail, Feras, Alemzadeh, Sayyed
Format: Journal Article
Sprache:Englisch
Veröffentlicht: India Wolters Kluwer India Pvt. Ltd 01.07.2018
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Knowledge E
Schlagworte:
Age
Agreements
Angiography
Cataracts
Central Foveal Subfield Thickness; Deep Capillary Plexus; Foveal Avascular Zone; Optical Coherence Tomography Angiography; Superficial Capillary Plexus; Vessel Density
Diabetes
Diabetic retinopathy
Medical imaging
Multivariate analysis
Original
Studies
Tomography
Superficial Capillary Plexus
Optical Coherence Tomography Angiography
Deep Capillary Plexus
Central Foveal Subfield Thickness
Vessel Density
Foveal Avascular Zone
ISSN:2008-322X, 2008-2010, 2008-322X
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Zusammenfassung:Purpose: To report the normal characteristics and correlations of the foveal microvascular networks using optical coherence tomography angiography (OCTA) in a healthy Iranian population. Methods: Enface 3x3 OCTA images were obtained using the RTVue Avanti spectral-domain optical coherence tomography with AngioVue software (Optovue, Fremont, CA, USA). Foveal avascular zone (FAZ) area, central foveal point thickness and inner retinal thickness at the foveal center and the vascular density of the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in the fovea were recorded. Results: Seventy normal eyes of 70 subjects (range, 9 to 71 years) were studied. Mean FAZ area was 0.32 ± 0.11 (range, 0.13-0.67) mm2 in SCP and 0.50 ± 0.13 (range, 0.19-0.94) mm2 in DCP. Mean SCP vessel density was 29.6 ± 4.7 (range, 16.3-40.3) % in the fovea. Mean DCP vessel density was 27.0 ± 5.9 (range, 15.0-45.2) % in the fovea. The FAZ area at SCP level was negatively correlated to the central subfield thickness (P < 0.001). The FAZ area at DCP level correlated negatively to the central subfield thickness and was significantly associated to age (both P < 0.001). The foveal SCP vessel density significantly correlated with foveal thickness and the foveal DCP vessel density correlated significantly with central foveal subfield thickness and was inversely related to age (all P < 0.05). Conclusion: In this study, central foveal subfield thickness was a major determinant of the FAZ size and foveal vessel density. Age was a determinant for FAZ area and whole image vessel density in DCP.
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ISSN:2008-322X
2008-2010
2008-322X
DOI:10.4103/jovr.jovr_173_17