In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain

The dynamic processes of formatting long-term memory traces in the cortex are poorly understood. The investigation of these processes requires measurements of task-evoked neuronal activities from large numbers of neurons over many days. Here, we present a two-photon imaging-based system to track eve...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 111; číslo 7; s. 2788
Hlavní autori:	Xie, Hong, Liu, Yu, Zhu, Youzhi, Ding, Xinlu, Yang, Yuhao, Guan, Ji-Song
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 18.02.2014
Predmet:	Animals Brain Mapping - methods Cerebral Cortex - cytology Cerebral Cortex - physiology Gene Expression - physiology Genes, Immediate-Early - genetics Genes, Immediate-Early - physiology Green Fluorescent Proteins - metabolism Image Processing, Computer-Assisted Memory, Long-Term - physiology Mice Microscopy, Fluorescence Neurons - metabolism Neurons - physiology
ISSN:	1091-6490, 1091-6490
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