Transfusion-related acute lung injury: a clinical review

Three decades ago, transfusion-related acute lung injury (TRALI) was considered a rare complication of transfusion medicine. Nowadays, the US Food and Drug Administration acknowledge the syndrome as the leading cause of transfusion-related mortality. Understanding of the pathogenesis of TRALI has re...

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Bibliographic Details
Published in:The Lancet (British edition) Vol. 382; no. 9896; pp. 984 - 994
Main Authors: Vlaar, Alexander PJ, Juffermans, Nicole P
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 14.09.2013
Elsevier
Elsevier Limited
Subjects:
Acute Lung Injury - diagnosis
Acute Lung Injury - etiology
Antibody Formation - physiology
Biological and medical sciences
Blood platelets
Blood transfusions
Cytokines
Cytokines - metabolism
Food and Drug Administration
General aspects
Humans
Internal Medicine
Lungs
Medical sciences
medicine
Mortality
Neutrophil Activation - immunology
Neutrophil Activation - physiology
Neutrophils - immunology
Pathogenesis
Patients
physicians
Pulmonary Edema - etiology
Risk factors
Sepsis
Studies
Surgery
Time Factors
Transfusion
Transfusion Reaction
United States
Ventilators
United States
Medicine
Review
Transfusion related acute lung injury
Bibliographic review
ISSN:0140-6736, 1474-547X, 1474-547X
Online Access:Get full text
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Summary:Three decades ago, transfusion-related acute lung injury (TRALI) was considered a rare complication of transfusion medicine. Nowadays, the US Food and Drug Administration acknowledge the syndrome as the leading cause of transfusion-related mortality. Understanding of the pathogenesis of TRALI has resulted in the design of preventive strategies from a blood-bank perspective. A major breakthrough in efforts to reduce the incidence of TRALI has been to exclude female donors of products with high plasma volume, resulting in a decrease of roughly two-thirds in incidence. However, this strategy has not completely eradicated the complication. In the past few years, research has identified patient-related risk factors for the onset of TRALI, which have empowered physicians to take an individualised approach to patients who need transfusion.
Bibliography:http://dx.doi.org/10.1016/S0140-6736(12)62197-7
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ISSN:0140-6736
1474-547X
1474-547X
DOI:10.1016/S0140-6736(12)62197-7