Reactive oxygen species in endothelial function - from disease to adaptation

Endothelial function is largely dictated by its ability to rapidly sense environmental cues and adapt to these stimuli through changes in vascular tone, inflammation/immune recruitment, and angiogenesis. When any one of these abilities is compromised, the endothelium becomes dysfunctional, which ult...

Full description

Saved in:
Bibliographic Details
Published in:Circulation journal : official journal of the Japanese Circulation Society Vol. 79; no. 6; p. 1145
Main Authors: Craige, Siobhan M, Kant, Shashi, Keaney, Jr, John F
Format: Journal Article
Language:English
Published: Japan 2015
Subjects:
Acetylcholine - pharmacology
Adaptation, Physiological
Animals
Cardiovascular Diseases - physiopathology
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Endothelium, Vascular - physiopathology
Endothelium-Dependent Relaxing Factors - physiology
Humans
Hypoxia - physiopathology
NADPH Oxidases - physiology
Neovascularization, Physiologic
Nitric Oxide - physiology
Nitric Oxide Synthase Type III - physiology
Reactive Oxygen Species - immunology
Reactive Oxygen Species - metabolism
Signal Transduction - physiology
Vascular Resistance - physiology
Vasculitis - immunology
Vasculitis - physiopathology
Vasodilation - physiology
ISSN:1347-4820, 1347-4820
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endothelial function is largely dictated by its ability to rapidly sense environmental cues and adapt to these stimuli through changes in vascular tone, inflammation/immune recruitment, and angiogenesis. When any one of these abilities is compromised, the endothelium becomes dysfunctional, which ultimately leads to disease. Reactive oxygen species (ROS) have been established at the forefront of endothelial dysfunction; however, more careful examination has demonstrated that ROS are fundamental to each of the sensing/signaling roles of the endothelium. The purpose of this review is to document endothelial ROS production in both disease and physiological adaptation. Through understanding new endothelial signaling paradigms, we will gain insight into more targeted therapeutic strategies for vascular diseases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1347-4820
1347-4820
DOI:10.1253/circj.CJ-15-0464