Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model

PD-1 (programmed-death 1), an immune-inhibitory receptor required for immune self-tolerance whose deficiency causes autoimmunity with variable severity and tissue specificity depending on other genetic factors, is expressed on activated T cells, including the transcription factor FoxP3(+) Treg cells...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 30; p. 8490
Main Authors:	Zhang, Baihao, Chikuma, Shunsuke, Hori, Shohei, Fagarasan, Sidonia, Honjo, Tasuku
Format:	Journal Article
Language:	English
Published:	United States 26.07.2016
Subjects:	Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmunity - genetics Autoimmunity - immunology Disease Models, Animal Forkhead Transcription Factors - genetics Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Gene Expression - immunology Humans Immune Tolerance - genetics Immune Tolerance - immunology Male Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Pancreatitis - genetics Pancreatitis - immunology Pancreatitis - metabolism Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - immunology Programmed Cell Death 1 Receptor - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T lymphocytes immune tolerance regulatory T cell autoimmunity PD-1
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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