Molecular and cellular mechanisms of food allergy and food tolerance

Ingestion of innocuous antigens, including food proteins, normally results in local and systemic immune nonresponsiveness in a process termed oral tolerance. Oral tolerance to food proteins is likely to be intimately linked to mechanisms that are responsible for gastrointestinal tolerance to large n...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 137; no. 4; pp. 984 - 997
Main Authors:	Chinthrajah, R. Sharon, Hernandez, Joseph D., Boyd, Scott D., Galli, Stephen J., Nadeau, Kari C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.04.2016 Elsevier Limited
Subjects:	Allergens - immunology Allergy and Immunology Antigens basophils Chemokines Cytokines Dendritic cells Dermatitis, Atopic - complications Dermatitis, Atopic - immunology desensitization Desensitization, Immunologic - methods Dietary Proteins - immunology Food Food allergies Food allergy Food Hypersensitivity - etiology Food Hypersensitivity - immunology Food Hypersensitivity - microbiology Food Hypersensitivity - therapy Gastrointestinal Microbiome Homeostasis Human subjects Humans Immune Tolerance Immunoglobulins Immunotherapy Inflammation Ligands Lymphatic system Lymphocytes mast cells microbiome Probiotics - therapeutic use Proteins regulatory T cells Risk Factors sensitization Studies T cell receptors tolerance Food allergy SLIT GALT regulatory T cells DNFB Treg GPR basophils mast cells microbiome SCFA desensitization MLN dendritic cells APC EPIT immunotherapy M cell sensitization OIT OVA Foxp3 tolerance DC Gut-associated lymphoid tissue Epicutaneous immunotherapy 2,4-Dinitrofluorobenzene Microfold cell Mesenteric lymph node Forkhead box protein 3 Regulatory T Antigen-presenting cell Dendritic cell Ovalbumin Sublingual immunotherapy Oral immunotherapy Short-chain fatty acid G protein–coupled receptor
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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