Comments on “Anatomically distinct fibroblast subsets determine skin autoimmune patterns”

[...]this study further revealed that in the pathogenesis of vitiligo, IFNγ-responsive dermal fibroblasts are not only uniquely required but also sufficient to induce local aggregation of CD8+ T cells. [...]blocking the activation signals may be a key approach to targeting fibroblasts. [...]targetin...

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Bibliographic Details
Published in:Chinese Medical Journal Vol. 135; no. 14; pp. 1695 - 1696
Main Authors: Chen, Yudi, Chang, Jianmin
Format: Journal Article
Language:English
Published: China Ovid Technologies (Wolters Kluwer Health) 20.07.2022
Lippincott Williams & Wilkins
Lippincott Williams & Wilkins Ovid Technologies
Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
Wolters Kluwer
Subjects:
Cells, Cultured
Chemokines
Commentary
Cytokines
Dermatology
Fibroblasts
Gene expression
Geriatrics
Gerontology
Lymphocytes
Medical research
Medicine
Pathogenesis
R
Regions
Skin
Skin diseases
Vitiligo
Beijing China
China
ISSN:0366-6999, 2542-5641, 2542-5641
Online Access:Get full text
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Summary:[...]this study further revealed that in the pathogenesis of vitiligo, IFNγ-responsive dermal fibroblasts are not only uniquely required but also sufficient to induce local aggregation of CD8+ T cells. [...]blocking the activation signals may be a key approach to targeting fibroblasts. [...]targeting these chemokine-chemokine receptor signaling and the downstream signaling proteins JAK1, JAK2, and STAT1 may also deserve further investigations. [...]we can perform gene ontology analysis on the transcriptome of fibroblast subtypes in mouse models and vitiligo patients to figure out the specific enrichment of IFN-γ pathway gene cell subsets. In the future, depleting vitiligo-specific pathogenic fibroblast subsets through targeting the potential distinct surface markers may serve as a possible treatment strategy.
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ISSN:0366-6999
2542-5641
2542-5641
DOI:10.1097/cm9.0000000000002303