GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement

Abstract Context GDF15 is a stress-induced hormone acting in the hindbrain that activates neural circuitry involved in establishing aversive responses and reducing food intake and body weight in animal models. Anorexia, weight loss, nausea and vomiting are common manifestations of glucocorticoid def...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 105; no. 5; pp. 1427 - 1434
Main Authors:	Melvin, Audrey, Chantzichristos, Dimitrios, Kyle, Catriona J, Mackenzie, Scott D, Walker, Brian R, Johannsson, Gudmundur, Stimson, Roland H, O’Rahilly, Stephen
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 01.05.2020 Copyright Oxford University Press
Subjects:	Addison Disease - blood Addison Disease - drug therapy Adolescent Adrenal Hyperplasia, Congenital - blood Adrenal Hyperplasia, Congenital - drug therapy Adrenal insufficiency Adrenal Insufficiency - blood Adrenal Insufficiency - drug therapy Adult Aged Animal models Anorexia Appetite Autoimmune diseases Body weight Body weight loss Care and treatment Clinical Cohort Studies Complications and side effects Corticosteroids Cross-Over Studies Endocrine disorders Endocrinology and Diabetes Endokrinologi och diabetes Female Food intake Glucocorticoids Glucocorticoids - blood Glucocorticoids - deficiency Glucocorticoids - therapeutic use Growth Differentiation Factor 15 - blood Health aspects Hindbrain Hormone Replacement Therapy Humans Hydrocortisone Hydrocortisone - blood Hydrocortisone - deficiency Hydrocortisone - therapeutic use Hyperplasia Intravenous administration Male Middle Aged Nausea Neural circuitry Neural networks Physiological aspects Single-Blind Method Transforming growth factors Up-Regulation Vomiting Young Adult United Kingdom GDF15 adrenal insufficiency glucocorticoids
ISSN:	0021-972X, 1945-7197, 1945-7197
Online Access:	Get full text
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