Genetic Characterization of Enterovirus A71 Circulating in Africa

We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribu...

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Veröffentlicht in:Emerging infectious diseases Jg. 24; H. 4; S. 754 - 757
Hauptverfasser: Fernandez-Garcia, Maria Dolores, Volle, Romain, Joffret, Marie-Line, Sadeuh-Mba, Serge Alain, Gouandjika-Vasilache, Ionela, Kebe, Ousmane, Wiley, Michael R., Majumdar, Manasi, Simon-Loriere, Etienne, Sakuntabhai, Anavaj, Palacios, Gustavo, Martin, Javier, Delpeyroux, Francis, Ndiaye, Kader, Bessaud, Maël
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States U.S. National Center for Infectious Diseases 01.04.2018
Centers for Disease Control and Prevention
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ISSN:1080-6040, 1080-6059, 1080-6059
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Abstract We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages.
AbstractList We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of geno-group C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochtho-nous EV-A that might contribute to the emergence of patho-genic lineages.
We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages.We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages.
We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa. Our analysis demonstrates wide geographic circulation and describes genetic exchanges between EV-A71 and autochthonous EV-A that might contribute to the emergence of pathogenic lineages.
Audience Professional
Academic
Author Joffret, Marie-Line
Kebe, Ousmane
Sadeuh-Mba, Serge Alain
Martin, Javier
Bessaud, Maël
Volle, Romain
Wiley, Michael R.
Ndiaye, Kader
Majumdar, Manasi
Gouandjika-Vasilache, Ionela
Delpeyroux, Francis
Simon-Loriere, Etienne
Sakuntabhai, Anavaj
Fernandez-Garcia, Maria Dolores
Palacios, Gustavo
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Issue 4
Keywords acute flaccid paralysis
phylogenetic analysis
viruses
recombination
enterovirus
Africa
enterovirus A71
whole-genome analysis
Language English
License Attribution: http://creativecommons.org/licenses/by
This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
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Snippet We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of genogroup C and the new genogroup E in West Africa....
We analyzed whole-genome sequences of 8 enterovirus A71 isolates (EV-A71). We confirm the circulation of geno-group C and the new genogroup E in West Africa....
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StartPage 754
SubjectTerms acute flaccid paralysis
Africa
Analysis
Dispatch
enterovirus
Enterovirus A, Human - classification
Enterovirus A, Human - genetics
enterovirus A71
Enterovirus Infections - epidemiology
Enterovirus Infections - virology
Genetic aspects
Genetic Variation
Genetics
Genome, Viral
Genomics
Genotype
Human health and pathology
Humans
Infectious diseases
Life Sciences
Nervous system diseases
Paralysis
phylogenetic analysis
Phylogeny
recombination
Recombination, Genetic
Santé publique et épidémiologie
Title Genetic Characterization of Enterovirus A71 Circulating in Africa
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