Disruption of hierarchical predictive coding during sleep

When presented with an auditory sequence, the brain acts as a predictive-coding device that extracts regularities in the transition probabilities between sounds and detects unexpected deviations from these regularities. Does such prediction require conscious vigilance, or does it continue to unfold...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS Jg. 112; H. 11; S. E1353
Hauptverfasser: Strauss, Melanie, Sitt, Jacobo D, King, Jean-Remi, Elbaz, Maxime, Azizi, Leila, Buiatti, Marco, Naccache, Lionel, van Wassenhove, Virginie, Dehaene, Stanislas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 17.03.2015
Schlagworte:
Adaptation, Physiological
Adolescent
Adult
Electroencephalography
Event-Related Potentials, P300 - physiology
Humans
Image Processing, Computer-Assisted
Magnetoencephalography
Sensation
Sleep - physiology
Sound
Wakefulness - physiology
Young Adult
prediction
mismatch response
magnetoencephalography
P300
MMN
ISSN:1091-6490, 1091-6490
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Zusammenfassung:When presented with an auditory sequence, the brain acts as a predictive-coding device that extracts regularities in the transition probabilities between sounds and detects unexpected deviations from these regularities. Does such prediction require conscious vigilance, or does it continue to unfold automatically in the sleeping brain? The mismatch negativity and P300 components of the auditory event-related potential, reflecting two steps of auditory novelty detection, have been inconsistently observed in the various sleep stages. To clarify whether these steps remain during sleep, we recorded simultaneous electroencephalographic and magnetoencephalographic signals during wakefulness and during sleep in normal subjects listening to a hierarchical auditory paradigm including short-term (local) and long-term (global) regularities. The global response, reflected in the P300, vanished during sleep, in line with the hypothesis that it is a correlate of high-level conscious error detection. The local mismatch response remained across all sleep stages (N1, N2, and REM sleep), but with an incomplete structure; compared with wakefulness, a specific peak reflecting prediction error vanished during sleep. Those results indicate that sleep leaves initial auditory processing and passive sensory response adaptation intact, but specifically disrupts both short-term and long-term auditory predictive coding.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.1501026112