Functional delivery of viral miRNAs via exosomes

Noncoding regulatory microRNAs (miRNAs) of cellular and viral origin control gene expression by repressing the translation of mRNAs into protein. Interestingly, miRNAs are secreted actively through small vesicles called "exosomes" that protect them from degradation by RNases, suggesting th...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 107; číslo 14; s. 6328
Hlavní autori:	Pegtel, D Michiel, Cosmopoulos, Katherine, Thorley-Lawson, David A, van Eijndhoven, Monique A J, Hopmans, Erik S, Lindenberg, Jelle L, de Gruijl, Tanja D, Würdinger, Thomas, Middeldorp, Jaap M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 06.04.2010
Predmet:	B-Lymphocytes - immunology B-Lymphocytes - secretion Cells, Cultured Coculture Techniques Dendritic Cells - immunology Dendritic Cells - secretion Exosomes - secretion Exosomes - ultrastructure Herpesvirus 4, Human - genetics Herpesvirus 4, Human - ultrastructure Humans MicroRNAs - genetics MicroRNAs - secretion Microscopy, Electron RNA, Viral - genetics RNA, Viral - secretion Virus Internalization
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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