Maximum entropy models for antibody diversity

Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building on recent experiments that provide a nearly exhaustive sampling of the IgM sequences in zebrafish. These models are based solely on pairwise...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 12; p. 5405
Main Authors:	Mora, Thierry, Walczak, Aleksandra M, Bialek, William, Callan, Jr, Curtis G
Format:	Journal Article
Language:	English
Published:	United States 23.03.2010
Subjects:	Amino Acid Sequence Animals Antibody Diversity Base Sequence Biophysical Phenomena DNA - chemistry DNA - genetics Entropy Evolution, Molecular Immunoglobulin M - chemistry Immunoglobulin M - genetics Models, Immunological Zebrafish - genetics Zebrafish - immunology Zebrafish Proteins - chemistry Zebrafish Proteins - genetics
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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