KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer's disease (AD) and related tauopathies. Here, we found that reduced levels of the memory-associated protein KIdney/BRAin (KIBRA) in the brain and increased KIBR...

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Veröffentlicht in:	The Journal of clinical investigation Jg. 134; H. 3; S. 1 - 18
Hauptverfasser:	Kauwe, Grant, Pareja-Navarro, Kristeen A., Yao, Lei, Chen, Jackson H., Wong, Ivy, Saloner, Rowan, Cifuentes, Helen, Nana, Alissa L., Shah, Samah, Li, Yaqiao, Le, David, Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Kramer, Joel H., Sacktor, Todd C., Schilling, Birgit, Gan, Li, Casaletto, Kaitlin B., Tracy, Tara E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Clinical Investigation 01.02.2024
Schlagworte:	Advertising executives Alzheimer Disease - pathology Alzheimer's disease Animals Biomarkers Brain Brain - metabolism C-Terminus Care and treatment Causes of Cerebrospinal fluid Cognition & reasoning Cognitive ability Complications and side effects Development and progression Disease Models, Animal Genetic engineering Health aspects Humans Immunological memory Kidney - metabolism Kinases Memory Memory Disorders - genetics Memory Disorders - metabolism Memory, Disorders of Mice Mice, Transgenic Neurodegenerative diseases Neuronal Plasticity Neurons Neuroplasticity Neuroscience Pathology Physiological aspects Protein kinases Recombinant proteins Resilience, Psychological Synapses Synaptic plasticity Tau protein Tau proteins tau Proteins - genetics tau Proteins - metabolism Tauopathies - genetics Tauopathies - metabolism Tauopathies - pathology Transgenic mice Canada California United States Neuroscience Alzheimer disease Memory Synapses
ISSN:	1558-8238, 0021-9738, 1558-8238
Online-Zugang:	Volltext
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