Noninvasive molecular imaging of small living subjects using Raman spectroscopy
Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We de...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 15; p. 5844 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
15.04.2008
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| Subjects: | |
| ISSN: | 1091-6490, 1091-6490 |
| Online Access: | Get more information |
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| Abstract | Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects. |
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| AbstractList | Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects. Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects.Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects. |
| Author | Cheng, Z Gambhir, S S Keren, S Gheysens, O Zavaleta, C de la Zerda, A |
| Author_xml | – sequence: 1 givenname: S surname: Keren fullname: Keren, S organization: Molecular Imaging Program at Stanford, Departments of Radiology and Bioengineering, Bio-X Program, Stanford University, 1201 Welch Road, Stanford, CA 94305-5484, USA – sequence: 2 givenname: C surname: Zavaleta fullname: Zavaleta, C – sequence: 3 givenname: Z surname: Cheng fullname: Cheng, Z – sequence: 4 givenname: A surname: de la Zerda fullname: de la Zerda, A – sequence: 5 givenname: O surname: Gheysens fullname: Gheysens, O – sequence: 6 givenname: S S surname: Gambhir fullname: Gambhir, S S |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18378895$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Diagnostic Imaging - methods Liver - cytology Liver - metabolism Liver - pathology Mice Nanoparticles - administration & dosage Phantoms, Imaging Spectrum Analysis, Raman - methods |
| Title | Noninvasive molecular imaging of small living subjects using Raman spectroscopy |
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