Noninvasive molecular imaging of small living subjects using Raman spectroscopy

Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We de...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS Jg. 105; H. 15; S. 5844
Hauptverfasser: Keren, S, Zavaleta, C, Cheng, Z, de la Zerda, A, Gheysens, O, Gambhir, S S
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.04.2008
Schlagworte:
Animals
Diagnostic Imaging - methods
Liver - cytology
Liver - metabolism
Liver - pathology
Mice
Nanoparticles - administration & dosage
Phantoms, Imaging
Spectrum Analysis, Raman - methods
ISSN:1091-6490, 1091-6490
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Zusammenfassung:Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.0710575105