Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis

To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps. To study the expression of TGF-β1, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs...

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Veröffentlicht in:	Journal of allergy and clinical immunology Jg. 125; H. 5; S. 1061 - 1068
Hauptverfasser:	Li, Xiaoyuan, Meng, Juan, Qiao, Xiaoming, Liu, Yafeng, Liu, Feng, Zhang, Nan, Zhang, Jie, Holtappels, Gabriele, Luo, Ba, Zhou, Peng, Zheng, Yongbo, Lin, Ping, Liu, Shixi, Bachert, Claus
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York, NY Mosby, Inc 01.05.2010 Elsevier Elsevier Limited
Schlagworte:	Adolescent Adult Allergy and Immunology Asian Continental Ancestry Group Asthma Biological and medical sciences Chinese patients Chronic Disease chronic rhinosinusitis collagen Disease Female forkhead box P3 (FOXP3) Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunoassay Immunopathology Male matrix metalloproteinase Matrix Metalloproteinases - metabolism Medical sciences Middle Aged nasal polyposis Nasal Polyps - complications Nasal Polyps - immunology Nasal Polyps - physiopathology Non tumoral diseases Otorhinolaryngology. Stomatology Patients Proteins regulatory T cells Rhinitis - complications Rhinitis - immunology Rhinitis - physiopathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sinuses Sinusitis - complications Sinusitis - immunology Sinusitis - physiopathology Studies Surgery TGF-β1 tissue inhibitor of metalloproteinase Tissue Inhibitor of Metalloproteinases - metabolism tissue remodeling Transforming Growth Factors - metabolism Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult Asia China NP CRS Treg collagen CRSwNP FOXP3 nasal polyposis CRSsNP ECM regulatory T cells CT MMP ECP tissue inhibitor of metalloproteinase chronic rhinosinusitis Chinese patients matrix metalloproteinase TGF-β1 tissue remodeling forkhead box P3 (FOXP3) TIMP Computed tomography Regulatory T Extracellular matrix Forkhead box P3 Chronic rhinosinusitis without nasal polyps Chronic rhinosinusitis with nasal polyps Eosinophil cationic protein Nose disease Rhinitis Transforming growth factor Metalloendopeptidases Remodeling Tissue inhibitor metalloproteinase Sinusitis Tissue Immunology T-Lymphocyte ENT disease Regulatory cell Transcription factor FOXP3 Human Immunopathology Enzyme Glycoprotein Peptidases Chronic Collagen Nasal polyposis Hydrolases Chinese Paranasal sinus disease Inhibitor Transforming growth factor β1
ISSN:	0091-6749, 1097-6825, 1097-6825
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Zusammenfassung:	To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps. To study the expression of TGF-β1, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), collagen, and regulatory T cells in Chinese patients with CRSwNP and CRSsNP. Thirty-six male and female subjects (12 patients with CRSwNP, 12 patients with CRSsNP, and 12 control subjects), age 17 to 60 years, were recruited into the study. Samples were collected from polyp and sinusoidal mucosal, ethmoidal mucosal, or inferior turbinate in the respective groups and assessed for TGF- β1, MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 by immunoassay; collagen by histochemistry; and forkhead box P3 (FOXP3) mRNA by real-time PCR. Patients with CRSwNP showed significantly lower concentrations of TGF-β1, TIMP-1, TIMP-4, FOXP3, and collagen compared with patients with CRSsNP. Although there were no significant differences between the concentrations of MMP-7 and MMP-9 in patients with CRSwNP and CRSsNP, these were significantly increased compared with control patients. MMP-2 and TIMP-2 concentrations were not significantly different in any patient group, whereas TIMP-3 was not detectable. Chronic rhinosinusitis with nasal polyps is characterized by a relative lack of TGF-ß expression versus CRSsNP. This finding may be causal for decreased collagen, TIMP-1/4, and FOXP3 expression in CRSwNP versus CRSsNP. TGF-ß serves as a main switch for different remodeling patterns in sinus disease.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0091-6749 1097-6825 1097-6825
DOI:	10.1016/j.jaci.2010.02.023