Asymptomatic and mild SARS-CoV-2 infections in a hungarian outpatient cohort in the first year of the covid-19 pandemic

We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation witho...

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Vydané v:Tropical medicine and infectious disease Ročník 8; číslo 4; s. 1 - 19
Hlavní autori: Jankovics, István, Müller, Cecília, Gönczöl, Éva, Visontai, Ildikó, Varga, István, Lőrincz, Márta, Kuti, Dávid, Hasitz, Ágnes, Malik, Péter, Ursu, Krisztina, Bányász, Borbála, Sarkadi, Júlia, Dénes, Béla
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Basel, Switzerland MDPI 29.03.2023
MDPI AG
Predmet:
2020-
Antibodies
Antigens
Asymptomatic
asymptomatic cases
Coronaviruses
COVID-19
COVID-19 (Disease)
COVID-19 Pandemic
Disease
Health aspects
Immunoglobulin A
Immunoglobulin G
Immunologic diseases
Infections
Laboratories
Medical research
Medicine, Experimental
Methodology
mild infections
outpatient cohort
Pandemics
Polymerase chain reaction
Prevention
Public health
Questionnaires
SARS-CoV-2
Scientific equipment and supplies industry
seroprevalence
Severe acute respiratory syndrome coronavirus 2
Social aspects
University students
Veterinary medicine
Hungary
United States
United States > US
COVID-19
mild infections
SARS-CoV-2
first year of the pandemic
Hungary
seroprevalence
outpatient cohort
asymptomatic cases
ISSN:2414-6366, 2414-6366
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Shrnutí:We aimed to estimate the proportion of the population infected with SARS-CoV-2 in the first year of the pandemic. The study population consisted of outpatient adults with mild or no COVID-19 symptoms and was divided into subpopulations with different levels of exposure. Among the subpopulation without known previous COVID-19 contacts, 4143 patients were investigated. Of the subpopulation with known COVID-19 contacts, 594 patients were investigated. IgG- and IgA- seroprevalence and RT-PCR positivity were determined in context with COVID-19 symptoms. Our results suggested no significant age-related differences between participants for IgG positivity but indicated that COVID-19 symptoms occurred most frequently in people aged between 20 and 29 years. Depending on the study population, 23.4-74.0% PCR-positive people (who were symptomless SARS- CoV-2 carriers at the time of the investigation) were identified. It was also observed that 72.7% of the patients remained seronegative for 30 days or more after their first PCR-positive results. This study hoped to contribute to the scientific understanding of the significance of asymptomatic and mild infections in the long persistence of the pandemic.
Bibliografia:Tropical Medicine and Infectious Disease, Vol. 8, No. 4, Apr 2023, 1-19
Informit, Melbourne (Vic)
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SourceType-Scholarly Journals-1
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ISSN:2414-6366
2414-6366
DOI:10.3390/tropicalmed8040204