Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor

Recognition of DNA by the innate immune system is central to antiviral and antibacterial defenses, as well as an important contributor to autoimmune diseases involving self DNA. AIM2 (absent in melanoma 2) and IFI16 (interferon-inducible protein 16) have been identified as DNA receptors that induce...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Jg. 36; H. 4; S. 561
Hauptverfasser:	Jin, Tengchuan, Perry, Andrew, Jiang, Jiansheng, Smith, Patrick, Curry, James A, Unterholzner, Leonie, Jiang, Zhaozhao, Horvath, Gabor, Rathinam, Vijay A, Johnstone, Ricky W, Hornung, Veit, Latz, Eicke, Bowie, Andrew G, Fitzgerald, Katherine A, Xiao, T Sam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.04.2012
Schlagworte:	Amino Acid Sequence Cell Line Crystallography, X-Ray DNA, B-Form - chemistry DNA, B-Form - immunology DNA, B-Form - metabolism DNA-Binding Proteins - chemistry Humans Immunity, Innate Inflammasomes - genetics Inflammasomes - metabolism Models, Molecular Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - metabolism Phosphoproteins - metabolism Protein Binding Protein Folding Protein Structure, Tertiary Signal Transduction
ISSN:	1097-4180, 1097-4180
Online-Zugang:	Weitere Angaben
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