Clinical Features and Outcome of Multidrug-Resistant Osteoarticular Tuberculosis: A 12-Year Case Series from France

The optimal treatment for osteoarticular infection due to multidrug-resistant tuberculosis strains (MDR-OATB) remains unclear. This study aims to evaluate the diagnosis, management and outcome of MDR-OATB in France. We present a case series of MDR-OATB patients reviewed at the French National Refere...

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Vydané v:Microorganisms Ročník 10; číslo 6; s. 1215
Hlavní autori: Bonnet, Isabelle, Haddad, Elie, Guglielmetti, Lorenzo, Bémer, Pascale, Bernard, Louis, Bourgoin, Anne, Brault, Rachel, Catho, Gaud, Caumes, Eric, Escaut, Lélia, Fourniols, Eric, Fréchet-Jachym, Mathilde, Gaudart, Alice, Guillot, Hélène, Lafon-Desmurs, Barthélémy, Lanoix, Jean-Philippe, Lanotte, Philippe, Lemaignen, Adrien, Lemaire, Bénédicte, Lemaitre, Nadine, Michau, Christophe, Morand, Philippe, Mougari, Faiza, Marigot-Outtandy, Dhiba, Patrat-Delon, Solène, Perpoint, Thomas, Piau, Caroline, Pourcher, Valérie, Zarrouk, Virginie, Zeller, Valérie, Veziris, Nicolas, Jauréguiberry, Stéphane, Aubry, Alexandra
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 14.06.2022
MDPI
Predmet:
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Biology (General)
Biomedical materials
bone
Bone surgery
Clinical outcomes
Drug resistance
Drugs
France
Health services
Human health and pathology
Life Sciences
Localization
Lymphatic system
males
MDR-TB
MDR-TB; XDR-TB; bone; spinal
medical history
Multidrug resistance
multiple drug resistance
Patients
QH301-705.5
spinal
Spine
Statistical analysis
Success
Surgery
Tuberculosis
XDR-TB
France
United States > US
MDR-TB
bone
XDR-TB
spinal
ISSN:2076-2607, 2076-2607
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Shrnutí:The optimal treatment for osteoarticular infection due to multidrug-resistant tuberculosis strains (MDR-OATB) remains unclear. This study aims to evaluate the diagnosis, management and outcome of MDR-OATB in France. We present a case series of MDR-OATB patients reviewed at the French National Reference Center for Mycobacteria between 2007 and 2018. Medical history and clinical, microbiological, treatment and outcome data were collected. Twenty-three MDR-OATB cases were reported, representing 3% of all concurrent MDR-TB cases in France. Overall, 17 were male, and the median age was 32 years. Six patients were previously treated for TB, including four with first-line drugs. The most frequently affected site was the spine (n = 16). Bone and joint surgery were required in 12 patients. Twenty-one patients (91%) successfully completed the treatment with a regimen containing a mean of four drugs (range, 2–6) for a mean duration of 20 months (range, 13–27). Overall, high rates of treatment success were achieved following WHO MDR-TB treatment guidelines and individualized patient management recommendations by the French National TB Consilium. However, the optimal combination of drugs, duration of treatment and role of surgery in the management of MDR-OATB remains to be determined.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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PMCID: PMC9229793
Collaborators/Membership of the Group/Team Name is provided in the Acknowledgments.
These authors contributed equally to this work.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10061215