The chronic and evolving neurological consequences of traumatic brain injury

Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement...

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Vydáno v:Lancet neurology Ročník 16; číslo 10; s. 813 - 825
Hlavní autoři: Wilson, Lindsay, Stewart, William, Dams-O'Connor, Kristen, Diaz-Arrastia, Ramon, Horton, Lindsay, Menon, David K, Polinder, Suzanne
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.10.2017
Elsevier Limited
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ISSN:1474-4422, 1474-4465, 1474-4465
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Abstract Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology, which includes chronic traumatic encephalopathy. Despite growing awareness of the lifelong consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.
AbstractList Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology, which includes chronic traumatic encephalopathy. Despite growing awareness of the lifelong consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualized as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology which includes chronic traumatic encephalopathy. Despite growing awareness of the life-long consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology, which includes chronic traumatic encephalopathy. Despite growing awareness of the lifelong consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology, which includes chronic traumatic encephalopathy. Despite growing awareness of the lifelong consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.
Author Horton, Lindsay
Diaz-Arrastia, Ramon
Stewart, William
Dams-O'Connor, Kristen
Menon, David K
Wilson, Lindsay
Polinder, Suzanne
AuthorAffiliation 2 Department of Neuropathology, Queen Elizabeth University Hospital, Glasgow and Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK
5 Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
4 Department of Neurology and Center for Brain Injury and Repair, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA
6 Department of Public Health, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
1 Division of Psychology, University of Stirling, Stirling, UK
3 Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
AuthorAffiliation_xml – name: 4 Department of Neurology and Center for Brain Injury and Repair, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA
– name: 2 Department of Neuropathology, Queen Elizabeth University Hospital, Glasgow and Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK
– name: 1 Division of Psychology, University of Stirling, Stirling, UK
– name: 5 Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
– name: 3 Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
– name: 6 Department of Public Health, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
Author_xml – sequence: 1
  givenname: Lindsay
  surname: Wilson
  fullname: Wilson, Lindsay
  email: j.t.l.wilson@stir.ac.uk
  organization: Division of Psychology, University of Stirling, Stirling, UK
– sequence: 2
  givenname: William
  surname: Stewart
  fullname: Stewart, William
  organization: Department of Neuropathology, Queen Elizabeth University Hospital, Glasgow, UK
– sequence: 3
  givenname: Kristen
  surname: Dams-O'Connor
  fullname: Dams-O'Connor, Kristen
  organization: Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
– sequence: 4
  givenname: Ramon
  surname: Diaz-Arrastia
  fullname: Diaz-Arrastia, Ramon
  organization: Department of Neurology and Center for Brain Injury and Repair, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
– sequence: 5
  givenname: Lindsay
  surname: Horton
  fullname: Horton, Lindsay
  organization: Division of Psychology, University of Stirling, Stirling, UK
– sequence: 6
  givenname: David K
  surname: Menon
  fullname: Menon, David K
  organization: Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
– sequence: 7
  givenname: Suzanne
  surname: Polinder
  fullname: Polinder, Suzanne
  organization: Department of Public Health, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28920887$$D View this record in MEDLINE/PubMed
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  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(15)00002-2
– volume: 71
  start-page: 1490
  year: 2014
  ident: 10.1016/S1474-4422(17)30279-X_bib63
  article-title: Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2014.2668
– reference: 28920875 - Lancet Neurol. 2017 Oct;16(10):766-768
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Snippet Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many...
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SubjectTerms Age
Brain Injuries, Traumatic - complications
Brain research
Chronic illnesses
Chronic Traumatic Encephalopathy - etiology
Cognition & reasoning
Cognitive ability
Collaboration
Concussion
Encephalopathy
Epilepsy
Epilepsy, Post-Traumatic - etiology
Hospitals
Humans
Mental Disorders - etiology
Mortality
Neurodegeneration
Neurodegenerative Diseases - etiology
Pathology
Population
Rehabilitation
Stroke - etiology
Trauma
Traumatic brain injury
Title The chronic and evolving neurological consequences of traumatic brain injury
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Volume 16
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