The chronic and evolving neurological consequences of traumatic brain injury

Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement...

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Podrobná bibliografie
Vydáno v:	Lancet neurology Ročník 16; číslo 10; s. 813 - 825
Hlavní autoři:	Wilson, Lindsay, Stewart, William, Dams-O'Connor, Kristen, Diaz-Arrastia, Ramon, Horton, Lindsay, Menon, David K, Polinder, Suzanne
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.10.2017 Elsevier Limited
Témata:	Age Brain Injuries, Traumatic - complications Brain research Chronic illnesses Chronic Traumatic Encephalopathy - etiology Cognition & reasoning Cognitive ability Collaboration Concussion Encephalopathy Epilepsy Epilepsy, Post-Traumatic - etiology Hospitals Humans Mental Disorders - etiology Mortality Neurodegeneration Neurodegenerative Diseases - etiology Pathology Population Rehabilitation Stroke - etiology Trauma Traumatic brain injury United States > US
ISSN:	1474-4422, 1474-4465, 1474-4465
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology, which includes chronic traumatic encephalopathy. Despite growing awareness of the lifelong consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Authors’ contributions All authors contributed to the formulation of the topic. LH did formal literature searches. LW, WS, KDO’C, and DKM prepared first drafts of the sections. All authors contributed to interpretation of the literature, and to revising and finalizing the manuscript.
ISSN:	1474-4422 1474-4465 1474-4465
DOI:	10.1016/S1474-4422(17)30279-X