Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish

Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity (ROHs) that arise when identical-by-descent (...

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Bibliographic Details
Published in:	BMC genomics Vol. 24; no. 1; pp. 134 - 9
Main Authors:	Lynch, Megan T., Maloney, Kristin A., Xu, Huichun, Perry, James A., Center, Regeneron Genetics, Shuldiner, Alan R., Mitchell, Braxton D.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 20.03.2023 BioMed Central Ltd BMC
Subjects:	Amish Amish - genetics Animal Genetics and Genomics Autozygosity Biomedical and Life Sciences Founder population genetics Genetic aspects Genetic research Genome Health aspects Homozygosity Homozygote Humans Inbreeding Life Sciences Microarrays Microbial Genetics and Genomics Multifactorial Inheritance Plant Genetics and Genomics Polymorphism, Single Nucleotide Population genetics Proteomics Runs of Homozygosity United States Autozygosity Runs of Homozygosity Amish Founder population genetics
ISSN:	1471-2164, 1471-2164
Online Access:	Get full text
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