Structural insights into the lipid and ligand regulation of serotonin receptors

Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter 1 , 2 that activates the largest subtype family of G-protein-coupled receptors 3 . Drugs that target 5-HT 1A , 5-HT 1D , 5-HT 1E and other 5-HT receptors are used to treat numerous disorders 4 . 5-HT receptors have high level...

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Vydáno v:	Nature (London) Ročník 592; číslo 7854; s. 469 - 473
Hlavní autoři:	Xu, Peiyu, Huang, Sijie, Zhang, Huibing, Mao, Chunyou, Zhou, X. Edward, Cheng, Xi, Simon, Icaro A., Shen, Dan-Dan, Yen, Hsin-Yung, Robinson, Carol V., Harpsøe, Kasper, Svensson, Bo, Guo, Jia, Jiang, Hualiang, Gloriam, David E., Melcher, Karsten, Jiang, Yi, Zhang, Yan, Xu, H. Eric
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 15.04.2021 Nature Publishing Group
Témata:	101/1 101/28 631/154/436/2387 631/45/776 631/535/1258/1259 82 82/80 82/83 Agonists Antipsychotic drugs Antipsychotics Apoproteins - chemistry Apoproteins - metabolism Apoproteins - ultrastructure Aripiprazole Aripiprazole - metabolism Aripiprazole - pharmacology Binding Binding Sites Biological control systems Cholesterol Cholesterol - pharmacology Coupling (molecular) Cryoelectron Microscopy G protein-coupled receptors Heterotrimeric GTP-Binding Proteins - chemistry Heterotrimeric GTP-Binding Proteins - metabolism Heterotrimeric GTP-Binding Proteins - ultrastructure Humanities and Social Sciences Humans Ligands Ligands (Biochemistry) Lipids Models, Molecular multidisciplinary Phenols Phosphatidylinositol 4-phosphate Phosphatidylinositol Phosphates - chemistry Phosphatidylinositol Phosphates - metabolism Phosphatidylinositol Phosphates - pharmacology Phospholipids Physiological aspects Physiological research Proteins Receptor, Serotonin, 5-HT1A - chemistry Receptor, Serotonin, 5-HT1A - metabolism Receptor, Serotonin, 5-HT1A - ultrastructure Receptors Receptors, Serotonin, 5-HT1 - chemistry Receptors, Serotonin, 5-HT1 - metabolism Receptors, Serotonin, 5-HT1 - ultrastructure Science Science (multidisciplinary) Serotonin Serotonin 5-HT1 Receptor Agonists - chemistry Serotonin 5-HT1 Receptor Agonists - metabolism Serotonin 5-HT1 Receptor Agonists - pharmacology Serotonin receptors Serotonin S1 receptors Structure Water - chemistry China
ISSN:	0028-0836, 1476-4687, 1476-4687
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