Characterization of Danube Swabian population samples on a high-resolution genome-wide basis

Background German-derived ethnicities are one of the largest ethnic groups in Hungary, dating back to the formation of the Kingdom of Hungary, which took place at the beginning of the 11th century. Germans arrived in Hungary in many waves. The most significant immigration wave took place following t...

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Vydané v:BMC genomics Ročník 24; číslo 1; s. 9 - 11
Hlavní autori: Bánfai, Zsolt, Kövesdi, Erzsébet, Sümegi, Katalin, Büki, Gergely, Szabó, András, Magyari, Lili, Ádám, Valerián, Pálos, Ferenc, Miseta, Attila, Kásler, Miklós, Melegh, Béla
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 09.01.2023
BioMed Central Ltd
BMC
Predmet:
Admixture
Aged
Animal Genetics and Genomics
Biomedical and Life Sciences
Emigration and immigration
Ethnic group
Ethnicity - genetics
Europe
Evaluation
Gene Frequency
Genetics, Population
Genome-wide data
Haplotype
Humans
Hungary
Life Sciences
Microarrays
Microbial Genetics and Genomics
Plant Genetics and Genomics
Population genetics
Proteomics
Swabians
Hungary
Europe
Swabians
Population genetics
Haplotype
Admixture
Ethnic group
Genome-wide data
ISSN:1471-2164, 1471-2164
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Shrnutí:Background German-derived ethnicities are one of the largest ethnic groups in Hungary, dating back to the formation of the Kingdom of Hungary, which took place at the beginning of the 11th century. Germans arrived in Hungary in many waves. The most significant immigration wave took place following the collapse of the Ottoman Empire in East-Central Europe which closed the 150 year long Ottoman occupation. To date, there are no comprehensive genome-wide studies investigating the genetic makeup of the Danube Swabians. Here we analyzed 47 Danube Swabian samples collected from elderly Swabian individuals living in the Dunaszekcső-Bár area, in Danube side villages of Southwest Hungary. These Swabians, according to self-declaration, did not admix with other ethnic groups for 3–6 succeeding generations. Using Illumina Infinium 720 K Beadchip genotype data, we applied allele frequency-based and haplotype-based genome-wide marker data analyses to investigate the ancestry and genetic composition of the collected Danube Swabian samples. Results Haplotype-based analyses like identity by descent segment analysis show that the investigated Danube Swabians possess significant German and other West European ancestry, but their Hungarian ancestry is also prominent. Our results suggest that their main source of ancestry can be traced back to Western Europe, presumably to the region of Germany. Conclusion This is the first analysis of Danube Swabian population samples based on genome-wide autosomal data. Our results establish the basis for conducting further comprehensive research on Danube Swabians and on other German ethnicities of the Carpathian basin, which can help reconstruct their origin, and identify their major archaic genomic patterns.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-022-09092-5