Cancer metabolism: a therapeutic perspective

Key Points The metabolic ecology of tumours enables component cells to generate ATP, maintain redox balance, and undertake biosynthesis, which in turn support tumour progression Tumours share features of complex ecosystems, with cancer cells inducing nutrient enrichment; however, the requirement for...

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Bibliographic Details
Published in:	Nature reviews. Clinical oncology Vol. 14; no. 1; pp. 11 - 31
Main Authors:	Martinez-Outschoorn, Ubaldo E., Peiris-Pagés, Maria, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.01.2017 Nature Publishing Group
Subjects:	692/420/755 692/699/67/1059/153 692/699/67/2327 692/699/67/2329 692/699/67/327 Acetyl Coenzyme A - metabolism Adaptation, Physiological Amino Acids - metabolism Antineoplastic Agents - therapeutic use Antioxidants - metabolism Autophagy - physiology Blood Glucose - metabolism Cancer cells Cell metabolism Energy Metabolism - drug effects Epigenomics Fatty Acids - metabolism Genetic Heterogeneity Glutamic Acid - metabolism Glutamine - metabolism Growth Health aspects Humans Innovations Ketone Bodies - metabolism Lactic Acid - metabolism Lipids - biosynthesis Medicine & Public Health Mitochondria - drug effects Mitochondrial Ribosomes - drug effects Molecular targeted therapy Neoplasms - drug therapy Neoplasms - metabolism Nucleic Acids - biosynthesis Oncology Oxidative Stress - drug effects Pyruvic Acid - metabolism review-article TOR Serine-Threonine Kinases - antagonists & inhibitors Transcription Factors - metabolism Tumor Microenvironment
ISSN:	1759-4774, 1759-4782
Online Access:	Get full text
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