Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small mole...

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Veröffentlicht in:	Nature (London) Jg. 514; H. 7523; S. 513 - 517
Hauptverfasser:	Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Welstead, G. Grant, Trimarchi, Thomas, Bakogianni, Sofia, Xu, Luyao, Loizou, Evangelia, Holmfeldt, Linda, Strikoudis, Alexandros, King, Bryan, Mullenders, Jasper, Becksfort, Jared, Nedjic, Jelena, Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., Tonon, Giovanni, Satoh, Takashi, Kruidenier, Laurens, Prinjha, Rab, Akira, Shizuo, Van Vlierberghe, Pieter, Ferrando, Adolfo A., Jaenisch, Rudolf, Mullighan, Charles G., Aifantis, Iannis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 23.10.2014 Nature Publishing Group
Schlagworte:	13/31 38 38/23 38/39 45 45/15 45/91 59/5 631/337/100/2285 631/67/1990/283 Animals Benzazepines - pharmacology Binding sites Epigenesis, Genetic - drug effects Genes Genetic aspects Genomes Health aspects Histone Demethylases - genetics Histone Demethylases - metabolism Histones Histones - chemistry Histones - metabolism Humanities and Social Sciences Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors Jumonji Domain-Containing Histone Demethylases - metabolism letter Leukemia Lymphocytic leukemia Lysine Lysine - metabolism Methylation - drug effects Methyltransferases Mice multidisciplinary Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Proteins Pyrimidines - pharmacology Science Studies Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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