Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging

There is an urgent need for quantitative magnetic resonance approaches for assessing brain development, as well as for studying the effects of drugs on neural tissue inflammation. Aviv Mezer and colleagues have developed a neuroimaging method for the quantification of local tissue volume and tissue-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature medicine Jg. 19; H. 12; S. 1667 - 1672
Hauptverfasser: Mezer, Aviv, Yeatman, Jason D, Stikov, Nikola, Kay, Kendrick N, Cho, Nam-Joon, Dougherty, Robert F, Perry, Michael L, Parvizi, Josef, Hua, Le H, Butts-Pauly, Kim, Wandell, Brian A
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.12.2013
Nature Publishing Group
Schlagworte:
631/1647/245/1628
631/378/2606/1666
692/53/2421
692/698/1688/64
Adult
Anatomy
Autoimmune diseases
Biomedicine
Brain
Brain - diagnostic imaging
Brain - pathology
Brain Mapping - methods
Cancer Research
Case-Control Studies
Cognition & reasoning
Female
Humans
Image Processing, Computer-Assisted - methods
Infectious Diseases
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical examination
Metabolic Diseases
Methods
Molecular Medicine
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Neuroimaging
Neurosciences
NMR
Nuclear magnetic resonance
Organ Size
Physiological aspects
Radiography
Reproducibility of Results
Studies
technical-report
Tissues
Validation Studies as Topic
United States
ISSN:1078-8956, 1546-170X, 1546-170X
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:There is an urgent need for quantitative magnetic resonance approaches for assessing brain development, as well as for studying the effects of drugs on neural tissue inflammation. Aviv Mezer and colleagues have developed a neuroimaging method for the quantification of local tissue volume and tissue-surface interaction, producing reliable quantitative measurements across a range of scanners. They apply their method to both the healthy brain and individuals with relapsing-remitting multiple sclerosis. Here, we describe a quantitative neuroimaging method to estimate the macromolecular tissue volume (MTV), a fundamental measure of brain anatomy. By making measurements over a range of field strengths and scan parameters, we tested the key assumptions and the robustness of the method. The measurements confirm that a consistent quantitative estimate of MTV can be obtained across a range of scanners. MTV estimates are sufficiently precise to enable a comparison between data obtained from an individual subject with control population data. We describe two applications. First, we show that MTV estimates can be combined with T1 and diffusion measurements to augment our understanding of the tissue properties. Second, we show that MTV provides a sensitive measure of disease status in individual patients with multiple sclerosis. The MTV maps are obtained using short clinically appropriate scans that can reveal how tissue changes influence behavior and cognition.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/nm.3390