Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging

There is an urgent need for quantitative magnetic resonance approaches for assessing brain development, as well as for studying the effects of drugs on neural tissue inflammation. Aviv Mezer and colleagues have developed a neuroimaging method for the quantification of local tissue volume and tissue-...

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Vydáno v:	Nature medicine Ročník 19; číslo 12; s. 1667 - 1672
Hlavní autoři:	Mezer, Aviv, Yeatman, Jason D, Stikov, Nikola, Kay, Kendrick N, Cho, Nam-Joon, Dougherty, Robert F, Perry, Michael L, Parvizi, Josef, Hua, Le H, Butts-Pauly, Kim, Wandell, Brian A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.12.2013 Nature Publishing Group
Témata:	631/1647/245/1628 631/378/2606/1666 692/53/2421 692/698/1688/64 Adult Anatomy Autoimmune diseases Biomedicine Brain Brain - diagnostic imaging Brain - pathology Brain Mapping - methods Cancer Research Case-Control Studies Cognition & reasoning Female Humans Image Processing, Computer-Assisted - methods Infectious Diseases Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical examination Metabolic Diseases Methods Molecular Medicine Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology Neuroimaging Neurosciences NMR Nuclear magnetic resonance Organ Size Physiological aspects Radiography Reproducibility of Results Studies technical-report Tissues Validation Studies as Topic United States
ISSN:	1078-8956, 1546-170X, 1546-170X
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Shrnutí:	There is an urgent need for quantitative magnetic resonance approaches for assessing brain development, as well as for studying the effects of drugs on neural tissue inflammation. Aviv Mezer and colleagues have developed a neuroimaging method for the quantification of local tissue volume and tissue-surface interaction, producing reliable quantitative measurements across a range of scanners. They apply their method to both the healthy brain and individuals with relapsing-remitting multiple sclerosis. Here, we describe a quantitative neuroimaging method to estimate the macromolecular tissue volume (MTV), a fundamental measure of brain anatomy. By making measurements over a range of field strengths and scan parameters, we tested the key assumptions and the robustness of the method. The measurements confirm that a consistent quantitative estimate of MTV can be obtained across a range of scanners. MTV estimates are sufficiently precise to enable a comparison between data obtained from an individual subject with control population data. We describe two applications. First, we show that MTV estimates can be combined with T1 and diffusion measurements to augment our understanding of the tissue properties. Second, we show that MTV provides a sensitive measure of disease status in individual patients with multiple sclerosis. The MTV maps are obtained using short clinically appropriate scans that can reveal how tissue changes influence behavior and cognition.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1078-8956 1546-170X 1546-170X
DOI:	10.1038/nm.3390