Translational strategies and challenges in regenerative medicine

Our understanding of stem cell biology is increasing, but the translation of this knowledge into regenerative medicine therapies for aged or diseased tissues is proving challenging. In this Perspective, four experts in the field discuss strategies for overcoming the major hurdles facing the translat...

Full description

Saved in:
Bibliographic Details
Published in:Nature medicine Vol. 20; no. 8; pp. 814 - 821
Main Authors: Dimmeler, Stefanie, Ding, Sheng, Rando, Thomas A, Trounson, Alan
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01.08.2014
Nature Publishing Group
Subjects:
631/532/1360
631/532/2139
631/532/489
692/700/565/2319
692/700/565/545/576/1955
Adult Stem Cells - cytology
Biology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell- and Tissue-Based Therapy - methods
Guided Tissue Regeneration
Hematopoietic Stem Cells - cytology
Humans
Infectious Diseases
Mesenchymal Stromal Cells - cytology
Metabolic Diseases
Molecular Medicine
Neurosciences
perspective
Regenerative Medicine - methods
Regrowth
Stem Cell Niche - physiology
Stem Cell Research
Stem Cell Transplantation
Stem cells
Tissue engineering
Tissue Engineering - methods
Wound Healing
California
ISSN:1078-8956, 1546-170X, 1546-170X
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Our understanding of stem cell biology is increasing, but the translation of this knowledge into regenerative medicine therapies for aged or diseased tissues is proving challenging. In this Perspective, four experts in the field discuss strategies for overcoming the major hurdles facing the translational regenerative field. The scientific community is currently witnessing substantial strides in understanding stem cell biology in humans; however, major disappointments in translating this knowledge into medical therapies are flooding the field as well. Despite these setbacks, investigators are determined to better understand the caveats of regeneration, so that major pathways of repair and regrowth can be exploited in treating aged and diseased tissues. Last year, in an effort to contribute to this burgeoning field, Nature Medicine , in collaboration with the Volkswagen Foundation, organized a meeting with a panel of experts in regenerative medicine to identify the most pressing challenges, as well as the crucial strategies and stem cell concepts that can best help advance the translational regenerative field. Here some experts who participated in the meeting provide an outlook at some of those key issues and concepts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/nm.3627