Translational strategies and challenges in regenerative medicine

Our understanding of stem cell biology is increasing, but the translation of this knowledge into regenerative medicine therapies for aged or diseased tissues is proving challenging. In this Perspective, four experts in the field discuss strategies for overcoming the major hurdles facing the translat...

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Vydáno v:Nature medicine Ročník 20; číslo 8; s. 814 - 821
Hlavní autoři: Dimmeler, Stefanie, Ding, Sheng, Rando, Thomas A, Trounson, Alan
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Nature Publishing Group US 01.08.2014
Nature Publishing Group
Témata:
631/532/1360
631/532/2139
631/532/489
692/700/565/2319
692/700/565/545/576/1955
Adult Stem Cells - cytology
Biology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell- and Tissue-Based Therapy - methods
Guided Tissue Regeneration
Hematopoietic Stem Cells - cytology
Humans
Infectious Diseases
Mesenchymal Stromal Cells - cytology
Metabolic Diseases
Molecular Medicine
Neurosciences
perspective
Regenerative Medicine - methods
Regrowth
Stem Cell Niche - physiology
Stem Cell Research
Stem Cell Transplantation
Stem cells
Tissue engineering
Tissue Engineering - methods
Wound Healing
California
ISSN:1078-8956, 1546-170X, 1546-170X
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Shrnutí:Our understanding of stem cell biology is increasing, but the translation of this knowledge into regenerative medicine therapies for aged or diseased tissues is proving challenging. In this Perspective, four experts in the field discuss strategies for overcoming the major hurdles facing the translational regenerative field. The scientific community is currently witnessing substantial strides in understanding stem cell biology in humans; however, major disappointments in translating this knowledge into medical therapies are flooding the field as well. Despite these setbacks, investigators are determined to better understand the caveats of regeneration, so that major pathways of repair and regrowth can be exploited in treating aged and diseased tissues. Last year, in an effort to contribute to this burgeoning field, Nature Medicine , in collaboration with the Volkswagen Foundation, organized a meeting with a panel of experts in regenerative medicine to identify the most pressing challenges, as well as the crucial strategies and stem cell concepts that can best help advance the translational regenerative field. Here some experts who participated in the meeting provide an outlook at some of those key issues and concepts.
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ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/nm.3627