Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli

•In vitro models may inform on the efficacy of antibiotic regimens against carbapenem-resistant Gram-negative bacilli.•High or moderate synergism was shown for polymyxin/rifampicin vs. A. baumannii and polymyxin/fosfomycin vs. K. pneumoniae.•High or moderate synergism was also shown for imipenem/ami...

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Bibliographic Details
Published in:	International journal of antimicrobial agents Vol. 57; no. 5; p. 106344
Main Authors:	Scudeller, Luigia, Righi, Elda, Chiamenti, Margherita, Bragantini, Damiano, Menchinelli, Giulia, Cattaneo, Paolo, Giske, Christian G., Lodise, Thomas, Sanguinetti, Maurizio, Piddock, Laura J.V., Franceschi, François, Ellis, Sally, Carrara, Elena, Savoldi, Alessia, Tacconelli, Evelina
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.05.2021
Subjects:	Acinetobacter baumannii amikacin Amikacin - pharmacology Anti-Bacterial Agents - pharmacology antibacterial properties Antibiotic combination Azabicyclo Compounds - pharmacology Carbapenem-resistant bacteria Carbapenems - pharmacology ceftazidime Ceftazidime - pharmacology Cephalosporins - pharmacology colistin Colistin - pharmacology confidence interval Drug Combinations Drug Resistance, Bacterial Drug Synergism Drug Therapy, Combination fosfomycin Fosfomycin - pharmacology Gram-Negative Bacteria - drug effects Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Humans imipenem Imipenem - pharmacology In vitro synergy In Vitro Techniques Infectious Disease Klebsiella pneumoniae meta-analysis Microbial Sensitivity Tests pharmacodynamics pharmacokinetics PK/PD Polymyxins - pharmacology Pseudomonas aeruginosa rifampicin Rifampin - pharmacology synergism systematic review Tazobactam - pharmacology therapeutics Time–kill tobramycin Tobramycin - pharmacology PK/PD Antibiotic combination Time–kill In vitro synergy Carbapenem-resistant bacteria in vitro synergy antibiotic combination carbapenem-resistant bacteria
ISSN:	0924-8579, 1872-7913, 1872-7913
Online Access:	Get full text
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