ESTRO ACROP and SIOPE recommendations for myeloablative Total Body Irradiation in children

•Toxicity reduction with outcome preservation is a goal of myeloablative TBI in children.•Fractionated TBI of 12–14.4 Gy, in 1.6–2 Gy fractions b.i.d. is advisable for children.•When possible, dose reduction to lungs (<8 Gy), kidneys (≤10 Gy) and lenses (<12 Gy) is appropriate.•Setup considera...

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Bibliographic Details
Published in:	Radiotherapy and Oncology Vol. 173; pp. 119 - 133
Main Authors:	Hoeben, Bianca A.W., Pazos, Montserrat, Seravalli, Enrica, Bosman, Mirjam E., Losert, Christoph, Albert, Michael H., Boterberg, Tom, Ospovat, Inna, Mico Milla, Soraya, Demiroz Abakay, Candan, Engellau, Jacob, Jóhannesson, Vilberg, Kos, Gregor, Supiot, Stéphane, Llagostera, Camille, Bierings, Marc, Scarzello, Giovanni, Seiersen, Klaus, Smith, Ed, Ocanto, Abrahams, Ferrer, Carlos, Bentzen, Søren M., Kobyzeva, Daria A., Loginova, Anna A., Janssens, Geert O.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01.08.2022 Elsevier BV
Subjects:	Bone Marrow Child Child, Preschool Consensus recommendations Cèl·lules mare hematopoètiques - Trasplantació - Complicacions Hematology Hematology, Oncology, and Palliative Medicine Hematopoietic stem cell transplantation Humans Infants Oncology Other subheadings::Other subheadings::/adverse effects [Other subheadings] Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores] Pediatric personas::Grupos de Edad::niño::niño preescolar [DENOMINACIONES DE GRUPOS] Persons::Age Groups::Child::Child, Preschool [NAMED GROUPS] Radiology Nuclear Medicine and imaging Radioteràpia Retrospective Studies terapéutica::radioterapia::irradiación corporal total [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] Therapeutics::Radiotherapy::Whole-Body Irradiation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] Total Body Irradiation Transplantation Conditioning Whole-Body Irradiation ALL MOSFET CRT IMRT MLC NRM ALT AYA CNS GVHD TLD TLI TMLI TPS CSI fTBI TBI SIOPE HSCT RT-qPCR Hematopoietic stem cell transplantation AML BED AST CML SSD IP sfTBI AP CVA CVD PA TMI Total Body Irradiation DEXA SOS SAD EQD2 NGS Pediatric MRD Consensus recommendations craniospinal irradiation sinusoidal obstruction syndrome alanine aminotransferase real-time quantitative polymerase chain reaction Non Relapse Mortality hematopoietic stem cell transplantation chronic myeloid leukemia cerebrovascular incident Total Marrow Irradiation interstitial pneumonitis central nervous system source to skin distance source-axis distance dose delivered in 2-Gy fractions that is biologically equivalent to a total dose intensity modulated radiation therapy European Society for Paediatric Oncology metal–oxide–semiconductor field-effect transistor Total Lymphoid Irradiation Dual-energy x-ray absorptiometry multileaf collimator treatment planning system acute myeloid leukemia EQD 2 adolescent and young adults thermoluminescent dosimeter Total Marrow and Lymphoid Irradiation cardiovascular disease next-generation sequencing Anterior-Posterior aspartate aminotransferase cranial radiotherapy single fraction Total Body Irradiation acute lymphoblastic leukemia biologically effective dose minimal residual disease Posterior-Anterior fractionated Total Body Irradiation graft versus host disease
ISSN:	0167-8140, 1879-0887, 1879-0887
Online Access:	Get full text
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