Master transcription factors and mediator establish super-enhancers at key cell identity genes

Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We report here that the ESC master transcription factors form unusual enhancer domains at most genes that control...

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Bibliographic Details

Published in:	Cell Vol. 153; no. 2; p. 307
Main Authors:	Whyte, Warren A, Orlando, David A, Hnisz, Denes, Abraham, Brian J, Lin, Charles Y, Kagey, Michael H, Rahl, Peter B, Lee, Tong Ihn, Young, Richard A
Format:	Journal Article
Language:	English
Published:	United States 11.04.2013
Subjects:	Animals B-Lymphocytes - metabolism Cell Line Cell Lineage Embryonic Stem Cells - metabolism Enhancer Elements, Genetic Gene Expression Regulation Gene Knockdown Techniques Humans Mediator Complex - metabolism Mice Transcription Factors - metabolism Transcription, Genetic
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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