Personalized MRI-based characterization of subcortical anomalies in Ataxia-Telangiectasia using deep-learning

Cerebellar atrophy is a known feature of ataxia-telangiectasia (A-T). However, basal ganglia dysfunction contributing to extrapyramidal movement disorders in A-T remains understudied. To characterize basal ganglia abnormalities in A-T using a normative self-supervised deep autoencoder trained on MRI...

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Vydáno v:	PloS one Ročník 20; číslo 8; s. e0328828
Hlavní autoři:	Saini, Catalina, Salazar-Vilches, Cristian, Blanchard, Caroline C.V., Whitehouse, William P., Parra, Denis, Dineen, Rob A., Pszczolkowski, Stefan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 29.08.2025 Public Library of Science (PLoS)
Témata:	Abnormalities Adolescent Anomalies Artificial intelligence Ataxia Ataxia telangiectasia Ataxia Telangiectasia - diagnostic imaging Ataxia Telangiectasia - pathology Atrophy Basal ganglia Basal Ganglia - diagnostic imaging Biology and Life Sciences Blood flow Cerebellum Cerebellum - diagnostic imaging Cerebellum - pathology Cerebral blood flow Cerebrovascular Circulation Child Datasets Deep Learning Demographic aspects Diagnosis Diffusion coefficient Dystonia Errors Female Flow mapping Ganglia Globus pallidus Health aspects Hippocampus Humans Kinases Machine learning Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Medicine and Health Sciences Movement disorders Neuroimaging Perfusion Putamen Reconstruction Research and Analysis Methods Research ethics Risk factors Substantia alba Substantia grisea Thalamus Chile Canada Calgary Alberta Canada
ISSN:	1932-6203, 1932-6203
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