Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process...

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Vydáno v:Lancet neurology Ročník 13; číslo 6; s. 614 - 629
Hlavní autoři: Dubois, Bruno, Feldman, Howard H, Jacova, Claudia, Hampel, Harald, Molinuevo, José Luis, Blennow, Kaj, DeKosky, Steven T, Gauthier, Serge, Selkoe, Dennis, Bateman, Randall, Cappa, Stefano, Crutch, Sebastian, Engelborghs, Sebastiaan, Frisoni, Giovanni B, Fox, Nick C, Galasko, Douglas, Habert, Marie-Odile, Jicha, Gregory A, Nordberg, Agneta, Pasquier, Florence, Rabinovici, Gil, Robert, Philippe, Rowe, Christopher, Salloway, Stephen, Sarazin, Marie, Epelbaum, Stéphane, de Souza, Leonardo C, Vellas, Bruno, Visser, Pieter J, Schneider, Lon, Stern, Yaakov, Scheltens, Philip, Cummings, Jeffrey L
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.06.2014
Elsevier Limited
Témata:
Alzheimer Disease
Alzheimer Disease - diagnosis
Alzheimer Disease - genetics
Alzheimer Disease - physiopathology
Alzheimer's disease
analysis
Biological Markers
Biomarkers
Biomarkers - analysis
Biomarkers - chemistry
chemistry
diagnosis
Fees & charges
genetics
Humans
Immunotherapy
International Cooperation
Medical
Memory
Neurologi
Neurology
Pathology
Pharmaceutical industry
Phenotype
physiopathology
Practice Guidelines as Topic
Practice Guidelines as Topic - standards
Societies
Societies, Medical - standards
ISSN:1474-4422, 1474-4465, 1474-4465
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Popis
Shrnutí:In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD.
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ISSN:1474-4422
1474-4465
1474-4465
DOI:10.1016/S1474-4422(14)70090-0