Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they ac...

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Podrobná bibliografie
Vydáno v:	Virus genes Ročník 55; číslo 6; s. 739 - 768
Hlavní autoři:	Suttie, Annika, Deng, Yi-Mo, Greenhill, Andrew R., Dussart, Philippe, Horwood, Paul F., Karlsson, Erik A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.12.2019 Springer Nature B.V Springer Verlag
Témata:	Animals Avian flu avian influenza Biochemistry, Molecular Biology Biomarkers Biomedical and Life Sciences Biomedicine Birds Birds - genetics Birds - virology Drug Resistance, Viral Drug Resistance, Viral - genetics Genetic Markers Genetic Markers - genetics Humans Influenza Influenza A Influenza A virus Influenza A Virus, H5N1 Subtype Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - pathogenicity Influenza A Virus, H7N9 Subtype Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - pathogenicity Influenza in Birds Influenza in Birds - epidemiology Influenza in Birds - genetics Influenza in Birds - virology Influenza, Human Influenza, Human - genetics Influenza, Human - virology Life Sciences mammals Medical Microbiology Microbiology and Parasitology mutation pandemic Pandemics pathogenesis Pathogenicity Plant Sciences Poultry Poultry - genetics Poultry - virology Review Paper risk Virology Zoonoses Zoonoses - genetics Zoonoses - virology Avian influenza Molecular marker Mutation Influenza virus Risk assessment Molecular inventory
ISSN:	0920-8569, 1572-994X, 1572-994X
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they acquire further mutations that facilitate human infection and/or increase pathogenesis. Molecular characterization of sequencing data for known genetic markers associated with AIV adaptation, transmission, and antiviral resistance allows for fast, efficient assessment of AIV risk. Here we summarize and update the current knowledge on experimentally verified molecular markers involved in AIV pathogenicity, receptor binding, replicative capacity, and transmission in both poultry and mammals with a broad focus to include data available on other AIV subtypes outside of A/H5N1 and A/H7N9.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23 PMCID: PMC6831541 Edited by William Dundon.
ISSN:	0920-8569 1572-994X 1572-994X
DOI:	10.1007/s11262-019-01700-z