Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness

Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and proliferating tumour cells. We show here that cell...

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Bibliographic Details
Published in:Scientific reports Vol. 10; no. 1; pp. 21634 - 12
Main Authors: Delespaul, Lucile, Gélabert, Caroline, Lesluyes, Tom, Le Guellec, Sophie, Pérot, Gaëlle, Leroy, Laura, Baud, Jessica, Merle, Candice, Lartigue, Lydia, Chibon, Frédéric
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 10.12.2020
Nature Publishing Group
Nature Portfolio
Subjects:
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Animals
Cell Differentiation
Cell Fusion
Fibroblasts
Genomic instability
Genomics
Heterografts
Humanities and Social Sciences
Humans
Leukocytes
Life Sciences
Mesenchymal Stem Cells - cytology
Mesenchyme
Metastases
Mice
multidisciplinary
Myoblasts
Sarcoma
Sarcoma - pathology
Science
Science (multidisciplinary)
Soft Tissue Neoplasms - pathology
Transcriptome
Tumorigenesis
Tumors
METASTASIS
GENE
FORMAT
DNA
SARCOMAS
CANCER
VARIANT
CHROMOSOMAL INSTABILITY
HYBRIDS
PLASTICITY
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and proliferating tumour cells. We show here that cell fusion between immortalized myoblasts and transformed fibroblasts, through genomic instability and expression of a specific transcriptomic profile, leads to emergence of hybrid cells acquiring dissemination properties. This is associated with acquisition of clonogenic ability by fused cells. In addition, by inheriting parental properties, hybrid tumours were found to mimic the histological characteristics of a specific histotype of sarcomas: undifferentiated pleomorphic sarcomas with incomplete muscular differentiation. This finding suggests that cell fusion, as macroevolution event, favours specific sarcoma development according to the differentiation lineage of parent cells.
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PMCID: PMC7729932
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-78502-z