Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness

Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and proliferating tumour cells. We show here that cell...

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Vydané v:	Scientific reports Ročník 10; číslo 1; s. 21634 - 12
Hlavní autori:	Delespaul, Lucile, Gélabert, Caroline, Lesluyes, Tom, Le Guellec, Sophie, Pérot, Gaëlle, Leroy, Laura, Baud, Jessica, Merle, Candice, Lartigue, Lydia, Chibon, Frédéric
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 10.12.2020 Nature Publishing Group Nature Portfolio
Predmet:	631/208 631/208/1405 631/208/211 631/208/212 631/208/720 631/208/726 631/67 631/67/1798 631/67/2329 631/67/68 631/67/69 631/67/70 Animals Cell Differentiation Cell Fusion Fibroblasts Genomic instability Genomics Heterografts Humanities and Social Sciences Humans Leukocytes Life Sciences Mesenchymal Stem Cells - cytology Mesenchyme Metastases Mice multidisciplinary Myoblasts Sarcoma Sarcoma - pathology Science Science (multidisciplinary) Soft Tissue Neoplasms - pathology Transcriptome Tumorigenesis Tumors METASTASIS GENE FORMAT DNA SARCOMAS CANCER VARIANT CHROMOSOMAL INSTABILITY HYBRIDS PLASTICITY
ISSN:	2045-2322, 2045-2322
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Shrnutí:	Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and proliferating tumour cells. We show here that cell fusion between immortalized myoblasts and transformed fibroblasts, through genomic instability and expression of a specific transcriptomic profile, leads to emergence of hybrid cells acquiring dissemination properties. This is associated with acquisition of clonogenic ability by fused cells. In addition, by inheriting parental properties, hybrid tumours were found to mimic the histological characteristics of a specific histotype of sarcomas: undifferentiated pleomorphic sarcomas with incomplete muscular differentiation. This finding suggests that cell fusion, as macroevolution event, favours specific sarcoma development according to the differentiation lineage of parent cells.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC7729932
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-78502-z