Diabetic retinopathy

Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complicati...

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Published in:	The Lancet (British edition) Vol. 376; no. 9735; pp. 124 - 136
Main Authors:	Cheung, Ning, Mitchell, Paul, Wong, Tien Yin
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 10.07.2010 Elsevier Elsevier Limited
Subjects:	Angiogenesis Biological and medical sciences Blindness Blood pressure Cardiovascular diseases Clinical trials Coronary heart disease Diabetes Diabetes mellitus Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - diagnosis Diabetic Retinopathy - physiopathology Diabetic Retinopathy - therapy Edema Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance General aspects Glucose Heart diseases Humans Hypothyroidism Industrialized nations Internal Medicine Lasers Lipids Medical sciences Microvasculature Older people Ophthalmology Pregnancy Preservation Retina Retinopathies Retinopathy Risk Factors Rural areas Steroid hormones Stroke Studies Surgery Endocrinopathy Medicine Eye disease Retinopathy Diabetes mellitus
ISSN:	0140-6736, 1474-547X, 1474-547X
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Abstract	Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising.
AbstractList	Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising. Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising. [PUBLICATION ABSTRACT] Summary Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising. Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising.Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising.
Author	Cheung, Ning Mitchell, Paul Wong, Tien Yin
Author_xml	– sequence: 1 givenname: Ning surname: Cheung fullname: Cheung, Ning organization: Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia – sequence: 2 givenname: Paul surname: Mitchell fullname: Mitchell, Paul organization: Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia – sequence: 3 givenname: Tien Yin surname: Wong fullname: Wong, Tien Yin email: ophwty@nus.edu.sg organization: Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
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Copyright	2010 Elsevier Ltd Elsevier Ltd 2015 INIST-CNRS Copyright 2010 Elsevier Ltd. All rights reserved. Copyright Elsevier Limited Jul 10-Jul 16, 2010 Copyright 2010 Elsevier Ltd. All rights reserved.
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Keywords	Endocrinopathy Medicine Eye disease Retinopathy Diabetes mellitus
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Snippet	Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged... Summary Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in...
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SubjectTerms	Angiogenesis Biological and medical sciences Blindness Blood pressure Cardiovascular diseases Clinical trials Coronary heart disease Diabetes Diabetes mellitus Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - diagnosis Diabetic Retinopathy - physiopathology Diabetic Retinopathy - therapy Edema Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance General aspects Glucose Heart diseases Humans Hypothyroidism Industrialized nations Internal Medicine Lasers Lipids Medical sciences Microvasculature Older people Ophthalmology Pregnancy Preservation Retina Retinopathies Retinopathy Risk Factors Rural areas Steroid hormones Stroke Studies Surgery
Title	Diabetic retinopathy
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