Diabetic retinopathy

Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complicati...

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Podrobná bibliografie
Vydáno v:	The Lancet (British edition) Ročník 376; číslo 9735; s. 124 - 136
Hlavní autoři:	Cheung, Ning, Mitchell, Paul, Wong, Tien Yin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Kidlington Elsevier Ltd 10.07.2010 Elsevier Elsevier Limited
Témata:	Angiogenesis Biological and medical sciences Blindness Blood pressure Cardiovascular diseases Clinical trials Coronary heart disease Diabetes Diabetes mellitus Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - diagnosis Diabetic Retinopathy - physiopathology Diabetic Retinopathy - therapy Edema Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance General aspects Glucose Heart diseases Humans Hypothyroidism Industrialized nations Internal Medicine Lasers Lipids Medical sciences Microvasculature Older people Ophthalmology Pregnancy Preservation Retina Retinopathies Retinopathy Risk Factors Rural areas Steroid hormones Stroke Studies Surgery Endocrinopathy Medicine Eye disease Retinopathy Diabetes mellitus
ISSN:	0140-6736, 1474-547X, 1474-547X
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Review-3
ISSN:	0140-6736 1474-547X 1474-547X
DOI:	10.1016/S0140-6736(09)62124-3