Diabetic retinopathy

Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complicati...

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Bibliographic Details
Published in:The Lancet (British edition) Vol. 376; no. 9735; pp. 124 - 136
Main Authors: Cheung, Ning, Mitchell, Paul, Wong, Tien Yin
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 10.07.2010
Elsevier
Elsevier Limited
Subjects:
Angiogenesis
Biological and medical sciences
Blindness
Blood pressure
Cardiovascular diseases
Clinical trials
Coronary heart disease
Diabetes
Diabetes mellitus
Diabetes. Impaired glucose tolerance
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - physiopathology
Diabetic Retinopathy - therapy
Edema
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
General aspects
Glucose
Heart diseases
Humans
Hypothyroidism
Industrialized nations
Internal Medicine
Lasers
Lipids
Medical sciences
Microvasculature
Older people
Ophthalmology
Pregnancy
Preservation
Retina
Retinopathies
Retinopathy
Risk Factors
Rural areas
Steroid hormones
Stroke
Studies
Surgery
Endocrinopathy
Medicine
Eye disease
Retinopathy
Diabetes mellitus
ISSN:0140-6736, 1474-547X, 1474-547X
Online Access:Get full text
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Summary:Diabetic retinopathy is a common and specific microvascular complication of diabetes, and remains the leading cause of preventable blindness in working-aged people. It is identified in a third of people with diabetes and associated with increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure. Optimum control of blood glucose, blood pressure, and possibly blood lipids remains the foundation for reduction of risk of retinopathy development and progression. Timely laser therapy is effective for preservation of sight in proliferative retinopathy and macular oedema, but its ability to reverse visual loss is poor. Vitrectomy surgery might occasionally be needed for advanced retinopathy. New therapies, such as intraocular injection of steroids and antivascular endothelial growth-factor agents, are less destructive to the retina than are older therapies, and could be useful in patients who respond poorly to conventional therapy. The outlook for future treatment modalities, such as inhibition of other angiogenic factors, regenerative therapy, and topical therapy, is promising.
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ISSN:0140-6736
1474-547X
1474-547X
DOI:10.1016/S0140-6736(09)62124-3