Transcriptome reveals the landscape of alveolar macrophages exposed to combined hypoxia with cigarette smoke extract

Background Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous chronic inflammatory disease that is one of the leading causes of age-standardised deaths globally. While studies have investigated altitude's effects on COPD, none have explored alveolar macrophage homeostat...

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Bibliographic Details
Published in:	Respiratory research Vol. 26; no. 1; pp. 241 - 14
Main Authors:	Liu, Qing, Zhang, Yushi, Duan, Ruirui, Li, Wanheng, Hou, Xuan, Chen, Yiling, Li, Baicun, Yang, Ting
Format:	Journal Article
Language:	English
Published:	London BioMed Central 10.07.2025 BioMed Central Ltd Nature Publishing Group BMC
Subjects:	Acids Altitude Alveolar macrophage homeostasis Alveoli Angiogenesis Animals Bioinformatics Cell Hypoxia - physiology Cells Cells, Cultured Chronic obstructive pulmonary disease Cigarette smoke Cigarette smoke extract Cigarette Smoking - adverse effects Cigarette Smoking - metabolism Cigarettes Disruption Enzymes Exposure Extracellular matrix Gene sequencing Glycolysis HIF-1α High altitude High-altitude environments Homeostasis Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Inflammatory diseases Lung diseases Macrophages Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Macrophages, Alveolar - pathology Medical research Medicine Medicine & Public Health Medicine, Experimental Mice Mice, Inbred C57BL Pathogenesis Physiological aspects Pneumology/Respiratory System Polarization Polymerase chain reaction Proteins Pulmonary alveoli Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - metabolism Ribonucleic acid RNA Sequence analysis Signal transduction Smoke Smoke - adverse effects Transcriptome - drug effects Transcriptome - physiology Transcriptomes China United States > US Hypoxia Chronic obstructive pulmonary disease HIF-1α Cigarette smoke extract Alveolar macrophage homeostasis
ISSN:	1465-993X, 1465-9921, 1465-993X
Online Access:	Get full text
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