Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

Background Endometrial cancer is the most common gynaecological cancer in high-income countries. Elevated body mass index (BMI) is an established modifiable risk factor for this condition and is estimated to confer a larger effect on endometrial cancer risk than any other cancer site. However, the m...

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Vydáno v:	BMC medicine Ročník 20; číslo 1; s. 125 - 24
Hlavní autoři:	Hazelwood, Emma, Sanderson, Eleanor, Tan, Vanessa Y., Ruth, Katherine S., Frayling, Timothy M., Dimou, Niki, Gunter, Marc J., Dossus, Laure, Newton, Claire, Ryan, Neil, Pournaras, Dimitri J., O’Mara, Tracy A., Davey Smith, George, Martin, Richard M., Yarmolinsky, James
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 19.04.2022 BioMed Central Ltd BMC
Témata:	Bioavailable testosterone Biological markers Biomedicine Body Mass Index Complications and side effects Endometrial cancer Endometrial Neoplasms - epidemiology Endometrial Neoplasms - genetics Fasting insulin Female Genetic aspects Genome-Wide Association Study Health aspects Hormones Humans Insulin Medicine Medicine & Public Health Mendelian randomization Mendelian Randomization Analysis Obesity Polymorphism, Single Nucleotide - genetics Prevention Research Article Risk Factors Sex hormone-binding globulin Testosterone United Kingdom Body mass index Bioavailable testosterone Sex hormone-binding globulin Mendelian randomization Endometrial cancer Fasting insulin
ISSN:	1741-7015, 1741-7015
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