Machine learning-driven development of a stratified CES-D screening system: optimizing depression assessment through adaptive item selection

Objective To develop a stratified screening tool through machine learning approaches for the Center for Epidemiologic Studies Depression Scale (CES-D-20) while maintaining diagnostic accuracy, addressing the efficiency limitations in large-scale applications. Methods Data were derived from the Chine...

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Vydané v:	BMC psychiatry Ročník 25; číslo 1; s. 286 - 20
Hlavní autori:	Xu, Ruo-Fei, Liu, Zhen-Jing, Ouyang, Shunan, Dong, Qin, Yan, Wen-Jing, Xu, Dong-Wu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 26.03.2025 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Accuracy Adolescent Age Algorithms CES-D Child Children & youth China Computational psychiatry Data collection Depression - diagnosis Depression screening Depression, Mental Depressive Disorder - diagnosis Discriminant analysis Epidemiology Feature selection Female Humans Learning algorithms Machine Learning Male Mass Screening - methods Medical screening Medicine Medicine & Public Health Mental depression Mental health Methods Predictive modeling Psychiatric Status Rating Scales Psychiatry Psychological aspects Psychometrics Psychotherapy Quantitative psychology Recursive Feature Elimination Stratified screening Technology application Teenagers China Taiwan CES-D Predictive modeling Recursive Feature Elimination Depression screening Machine learning Stratified screening
ISSN:	1471-244X, 1471-244X
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Popis
Shrnutí:	Objective To develop a stratified screening tool through machine learning approaches for the Center for Epidemiologic Studies Depression Scale (CES-D-20) while maintaining diagnostic accuracy, addressing the efficiency limitations in large-scale applications. Methods Data were derived from the Chinese Psychological Health Guard Project (primary sample: n = 179,877; age 9–18) and China Labor-force Dynamics Survey (validation samples across age spans). We employed a two-stage machine learning approach: first applying Recursive Feature Elimination with multiple linear regression to identify core predictive items for total depression scores, followed by logistic regression for optimizing depression classification (CES-D ≥ 16). Model performance was systematically evaluated through discrimination (ROC analysis), calibration (Brier score), and clinical utility analyses (decision curve analysis), with additional validation using random forest and support vector machine algorithms across independent samples. Results The resulting stratified screening system consists of an initial four-item rapid screening layer (encompassing emotional, cognitive, and interpersonal dimensions) for detecting probable depression (AUC = 0.982, sensitivity = 0.945, specificity = 0.926), followed by an enhanced assessment layer with five additional items. Together, these nine items enable accurate prediction of the full CES-D-20 total score (R 2 = 0.957). This stratified approach demonstrated robust generalizability across age groups (R 2 > 0.94, accuracy > 0.91) and time points. Calibration analyses and decision curve analyses confirmed optimal clinical utility, particularly in the critical risk threshold range (0.3–0.6). Conclusions This study contributes to the refinement of CES-D by developing a machine learning-derived stratified screening version, offering an efficient and reliable approach that optimizes assessment burden while maintaining excellent psychometric properties. The stratified design makes it particularly valuable for large-scale mental health screening programs, enabling efficient risk stratification and targeted assessment allocation.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1471-244X 1471-244X
DOI:	10.1186/s12888-025-06693-8