An MRI study of age-related white and gray matter volume changes in the rhesus monkey

We applied the automated MRI segmentation technique Template Driven Segmentation (TDS) to dual-echo spin echo (DE SE) images of eight young (5–12 years), six middle-aged (16–19 years) and eight old (24–30 years) rhesus monkeys. We analyzed standardized mean volumes for 18 anatomically defined region...

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Vydáno v:	Neurobiology of aging Ročník 29; číslo 10; s. 1563 - 1575
Hlavní autoři:	Wisco, Jonathan J., Killiany, Ronald J., Guttmann, Charles R.G., Warfield, Simon K., Moss, Mark B., Rosene, Douglas L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.10.2008
Témata:	Aging Aging - pathology Alzheimer Disease - pathology Alzheimer Disease - physiopathology Animals Atrophy - pathology Atrophy - physiopathology Brain - pathology Brain - physiopathology Brain Mapping Cerebral cortex Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cognition Disorders - etiology Cognition Disorders - pathology Cognition Disorders - physiopathology Disease Progression Gray matter Internal Medicine Macaca mulatta - anatomy & histology Macaca mulatta - physiology Magnetic Resonance Imaging Male Memory Disorders - pathology Memory Disorders - physiopathology MRI Nerve Fibers, Myelinated - pathology Neurology Neuropsychological Tests Organ Size Rhesus monkey Template Driven Segmentation (TDS) White matter Rhesus monkey Cerebral cortex MRI Aging White matter Gray matter Template Driven Segmentation (TDS)
ISSN:	0197-4580, 1558-1497, 1558-1497
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Shrnutí:	We applied the automated MRI segmentation technique Template Driven Segmentation (TDS) to dual-echo spin echo (DE SE) images of eight young (5–12 years), six middle-aged (16–19 years) and eight old (24–30 years) rhesus monkeys. We analyzed standardized mean volumes for 18 anatomically defined regions of interest (ROI's) and found an overall decrease from young to old age in the total forebrain (5.01%), forebrain parenchyma (5.24%), forebrain white matter (11.53%), forebrain gray matter (2.08%), caudate nucleus (11.79%) and globus pallidus (18.26%). Corresponding behavioral data for five of the young, five of the middle-aged and seven of the old subjects on the Delayed Non-matching to Sample (DNMS) task, the Delayed-recognition Span Task (DRST) and the Cognitive Impairment Index (CII) were also analyzed. We found that none of the cognitive measures were related to ROI volume changes in our sample size of monkeys.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0197-4580 1558-1497 1558-1497
DOI:	10.1016/j.neurobiolaging.2007.03.022