An MRI study of age-related white and gray matter volume changes in the rhesus monkey

We applied the automated MRI segmentation technique Template Driven Segmentation (TDS) to dual-echo spin echo (DE SE) images of eight young (5–12 years), six middle-aged (16–19 years) and eight old (24–30 years) rhesus monkeys. We analyzed standardized mean volumes for 18 anatomically defined region...

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Published in:Neurobiology of aging Vol. 29; no. 10; pp. 1563 - 1575
Main Authors: Wisco, Jonathan J., Killiany, Ronald J., Guttmann, Charles R.G., Warfield, Simon K., Moss, Mark B., Rosene, Douglas L.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.10.2008
Subjects:
Aging
Aging - pathology
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Animals
Atrophy - pathology
Atrophy - physiopathology
Brain - pathology
Brain - physiopathology
Brain Mapping
Cerebral cortex
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Cognition Disorders - etiology
Cognition Disorders - pathology
Cognition Disorders - physiopathology
Disease Progression
Gray matter
Internal Medicine
Macaca mulatta - anatomy & histology
Macaca mulatta - physiology
Magnetic Resonance Imaging
Male
Memory Disorders - pathology
Memory Disorders - physiopathology
MRI
Nerve Fibers, Myelinated - pathology
Neurology
Neuropsychological Tests
Organ Size
Rhesus monkey
Template Driven Segmentation (TDS)
White matter
Rhesus monkey
Cerebral cortex
MRI
Aging
White matter
Gray matter
Template Driven Segmentation (TDS)
ISSN:0197-4580, 1558-1497, 1558-1497
Online Access:Get full text
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Summary:We applied the automated MRI segmentation technique Template Driven Segmentation (TDS) to dual-echo spin echo (DE SE) images of eight young (5–12 years), six middle-aged (16–19 years) and eight old (24–30 years) rhesus monkeys. We analyzed standardized mean volumes for 18 anatomically defined regions of interest (ROI's) and found an overall decrease from young to old age in the total forebrain (5.01%), forebrain parenchyma (5.24%), forebrain white matter (11.53%), forebrain gray matter (2.08%), caudate nucleus (11.79%) and globus pallidus (18.26%). Corresponding behavioral data for five of the young, five of the middle-aged and seven of the old subjects on the Delayed Non-matching to Sample (DNMS) task, the Delayed-recognition Span Task (DRST) and the Cognitive Impairment Index (CII) were also analyzed. We found that none of the cognitive measures were related to ROI volume changes in our sample size of monkeys.
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ISSN:0197-4580
1558-1497
1558-1497
DOI:10.1016/j.neurobiolaging.2007.03.022