Geographic Information System and tools of spatial analysis in a pneumococcal vaccine trial

Background The goal of this Geographic Information System (GIS) study was to obtain accurate information on the locations of study subjects, road network and services for research purposes so that the clinical outcomes of interest (e.g., vaccine efficacy, burden of disease, nasopharyngeal colonizati...

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Vydáno v:BMC research notes Ročník 5; číslo 1; s. 51
Hlavní autoři: Tanskanen, Antti, Nillos, Leilani T, Lehtinen, Antti, Nohynek, Hanna, Sanvictores, Diozele Hazel M, Simões, Eric AF, Tallo, Veronica L, Lucero, Marilla G
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 20.01.2012
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Biomedical and Life Sciences
Biomedicine
Clinical trials
Colonization
Correspondence
Data processing
Developing countries
Geographic information systems
Health aspects
Hospitals
Immunity
Life Sciences
Medicine/Public Health
Pneumococcal infections
Pneumococcal vaccine
Prevention
Public health
Streptococcus pneumoniae
Vaccines
United States
Philippines
Finland
Road Network
Global Position System
Geographic Information System
Global Position System Data
Vaccine Trial
ISSN:1756-0500, 1756-0500
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Shrnutí:Background The goal of this Geographic Information System (GIS) study was to obtain accurate information on the locations of study subjects, road network and services for research purposes so that the clinical outcomes of interest (e.g., vaccine efficacy, burden of disease, nasopharyngeal colonization and its reduction) could be linked and analyzed at a distance from health centers, hospitals, doctors and other important services. The information on locations can be used to investigate more accurate crowdedness, herd immunity and/or transmission patterns. Method A randomized, placebo-controlled, double-blind trial of an 11-valent pneumococcal conjugate vaccine (11PCV) was conducted in Bohol Province in central Philippines, from July 2000 to December 2004. We collected the information on the geographic location of the households (N = 13,208) of study subjects. We also collected a total of 1982 locations of health and other services in the six municipalities and a comprehensive GIS data over the road network in the area. Results We calculated the numbers of other study subjects (vaccine and placebo recipients, respectively) within the neighborhood of each study subject. We calculated distances to different services and identified the subjects sharing the same services (calculated by distance). This article shows how to collect a complete GIS data set for human to human transmitted vaccine study in developing country settings in an efficient and economical way. Conclusions The collection of geographic locations in intervention trials should become a routine task. The results of public health research may highly depend on spatial relationships among the study subjects and between the study subjects and the environment, both natural and infrastructural. Trial registration number ISRCTN: ISRCTN62323832
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ISSN:1756-0500
1756-0500
DOI:10.1186/1756-0500-5-51